American Airlines flight AA 4380: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 08:14 Philadelphia (PHL) 10:22 Louisville (SDF)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:08 Effective 2025-09-03 through 2025-10-05
Daily 10:56 Louisville (SDF) 12:55 Philadelphia (PHL)
AA 4380 Non-stop Embraer EMB 175 (E75) 1:59 Effective 2025-09-03 through 2025-10-05
Mon-Fri 11:02 Cincinnati (CVG) 12:59 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:57 Effective 2025-06-06 through 2025-07-03
Mon-Fri 11:02 Cincinnati (CVG) 12:59 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:57 Effective 2025-07-07 through 2025-08-05
Fri 11:03 Cincinnati (CVG) 13:00 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:57 Operates only on 2025-07-04
Sun 11:04 Cincinnati (CVG) 13:00 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2025-07-06 through 2025-08-03
Sun 11:06 Cincinnati (CVG) 13:00 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 175 (E75) 1:54 Effective 2025-06-08 through 2025-06-29
Thu 12:02 Cincinnati (CVG) 13:59 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:57 Operates only on 2025-06-05
Sat 14:58 Cleveland Hopkins (CLE) 18:01 Miami (MIA)
AA 4380 Non-stop Embraer EMB 175 (E75) 3:03 Effective 2025-07-05 through 2025-08-02
Daily 15:05 Chicago O'Hare (ORD) 3 17:07 Tulsa (TUL)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:02 Valid until 2025-05-04
Sat 15:05 Cleveland Hopkins (CLE) 18:03 Miami (MIA)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:58 Effective 2025-06-07 through 2025-06-28
Mon-Fri,Sun 16:54 Chicago O'Hare (ORD) 3 18:54 Tulsa (TUL)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:00 Effective 2025-05-05 through 2025-06-04
Sat 17:10 Chicago O'Hare (ORD) 3 19:10 Tulsa (TUL)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:00 Effective 2025-05-10 through 2025-05-31
Tue,Sat 17:37 Tulsa (TUL) 19:41 Chicago O'Hare (ORD) 3
AA 4380 Non-stop Embraer EMB 175 (E75) 2:04 Valid until 2025-05-03
Daily 18:00 Nashville (BNA) 21:23 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 175 (E75) 2:23 Effective 2025-08-06 through 2025-09-02
Mon,Wed-Fri,Sun 19:11 Tulsa (TUL) 21:15 Chicago O'Hare (ORD) 3
AA 4380 Non-stop Embraer EMB 175 (E75) 2:04 Valid until 2025-05-04
Mon-Fri,Sun 19:24 Tulsa (TUL) 21:28 Chicago O'Hare (ORD) 3
AA 4380 Non-stop Embraer EMB 175 (E75) 2:04 Effective 2025-05-05 through 2025-06-04
Sat 19:40 Tulsa (TUL) 21:44 Chicago O'Hare (ORD) 3
AA 4380 Non-stop Embraer EMB 175 (E75) 2:04 Effective 2025-05-10 through 2025-05-17
Sat 19:40 Tulsa (TUL) 21:44 Chicago O'Hare (ORD) 3
AA 4380 Non-stop Embraer EMB 175 (E75) 2:04 Operates only on 2025-05-31
Daily 20:20 Chicago O'Hare (ORD) 3 22:38 Tulsa (TUL)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:18 Effective 2025-10-06 through 2025-11-01
Daily 20:20 Chicago O'Hare (ORD) 3 22:43 Tulsa (TUL)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:23 Effective 2025-12-18 through 2026-01-05
Daily 20:20 Chicago O'Hare (ORD) 3 22:29 Tulsa (TUL)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:09 Effective from 2026-02-12
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4380: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4380
08:14
Philadelphia (PHL)

10:22
Louisville (SDF)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:08, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
10:56
Louisville (SDF)

12:55
Philadelphia (PHL)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:59, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
11:02
Cincinnati (CVG)

12:59
New York LaGuardia (LGA) B
Effective 2025-06-06 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:57, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4380
11:02
Cincinnati (CVG)

12:59
New York LaGuardia (LGA) B
Effective 2025-07-07 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:57, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4380
11:03
Cincinnati (CVG)

13:00
New York LaGuardia (LGA) B
Operates only on 2025-07-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 1:57, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4380
11:04
Cincinnati (CVG)

13:00
New York LaGuardia (LGA) B
Effective 2025-07-06 through 2025-08-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
11:06
Cincinnati (CVG)

13:00
New York LaGuardia (LGA) B
Effective 2025-06-08 through 2025-06-29
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:54, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
12:02
Cincinnati (CVG)

13:59
New York LaGuardia (LGA) B
Operates only on 2025-06-05
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:57, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4380
14:58
Cleveland Hopkins (CLE)

18:01
Miami (MIA)
Effective 2025-07-05 through 2025-08-02
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:03, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
15:05
Chicago O'Hare (ORD) 3

17:07
Tulsa (TUL)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:02, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
15:05
Cleveland Hopkins (CLE)

18:03
Miami (MIA)
Effective 2025-06-07 through 2025-06-28
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:58, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
16:54
Chicago O'Hare (ORD) 3

18:54
Tulsa (TUL)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:00, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
17:10
Chicago O'Hare (ORD) 3

19:10
Tulsa (TUL)
Effective 2025-05-10 through 2025-05-31
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:00, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
17:37
Tulsa (TUL)

19:41
Chicago O'Hare (ORD) 3
Valid until 2025-05-03
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
18:00
Nashville (BNA)

21:23
New York LaGuardia (LGA) B
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:23, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
19:11
Tulsa (TUL)

21:15
Chicago O'Hare (ORD) 3
Valid until 2025-05-04
Mon
Tue
-
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
19:24
Tulsa (TUL)

21:28
Chicago O'Hare (ORD) 3
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
19:40
Tulsa (TUL)

21:44
Chicago O'Hare (ORD) 3
Effective 2025-05-10 through 2025-05-17
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
19:40
Tulsa (TUL)

21:44
Chicago O'Hare (ORD) 3
Operates only on 2025-05-31
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
20:20
Chicago O'Hare (ORD) 3

22:38
Tulsa (TUL)
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:18, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
20:20
Chicago O'Hare (ORD) 3

22:43
Tulsa (TUL)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:23, non-stop
Embraer EMB 175 (E75)
American Airlines AA4380
20:20
Chicago O'Hare (ORD) 3

22:29
Tulsa (TUL)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Chicago O'Hare (ORD) - Tulsa (TUL)
  • Cincinnati (CVG) - New York LaGuardia (LGA)
  • Cleveland Hopkins (CLE) - Miami (MIA)
  • Louisville (SDF) - Philadelphia (PHL)
  • Nashville (BNA) - New York LaGuardia (LGA)
All American Airlines flights
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